The positive resistance genes included CYP24A1, DNAJC12, EREG, NPTX1, PAEP,, and TRPM8. Meanwhile, the negative resistance genes included EMP2, HIGD1B and ADH1C. Meta-analysis for pooled HRs of first progression survival between lung cancer patients who highly expressed these genes and who lowly expressed these genes was conducted and it was found that the pooled HRs (95% CIs) of positive resistance genes were 1.52 (1.33, 1.72) while pooled HRs (95% CIs) of negative resistance genes were 0.59 (0.52, 0.66) (Fig. 2C). The gene discussed is HIGD1B; the disease is lung cancer.