APOB and abetalipoproteinemia: Abetalipoproteinemia (ABL, OMIM:200,100) is a systemic disease caused by errors in lipid metabolism that manifests by the absence of apolipoproteins b, very low density of lipoproteins and low density lipoproteins in the plasma [119], in addition to diarrhea caused by fat mal absorption, acanthocytosis and retinal dystrophy [112, 119].