CASP3 and neoplasm: Notably, caspase-3-mediated signaling following radiation or chemotherapy has been found to increase VEGF production from treated cancer cells (Cheng et al., 2019; Feng et al., 2017) and thereby promote tumor regrowth by inducing angiogenesis (Bernard et al., 2019; Cheng et al., 2019; Feng et al., 2015, 2017).