CASP3 and amyotrophic lateral sclerosis: Of interest in this regard is the possibility that caspase-3 might be a therapeutic target for preserving degenerating neuronal cells in neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS; Khan et al., 2015).