MTOR and cancer: Recent findings also indicate that the HGFR/mechanistic target of rapamycin (mTOR)/Unc-51 Like Autophagy Activating Kinase 1 (ULK1) cascade is responsible for HGFR-mediated autophagy, hence targeting autophagy may potentiate antitumor activity of HGFR-tyrosine kinases against Met-amplified cancer cells [12, 15, 18].