In the UEMS, determinants of a higher NAFLD prevalence were factors such as older age, female sex, higher waist-hip circumference ratio, lower depression score, higher serum concentrations of creatinine and bilirubine, lower prothrombin index, lower ankle-brachial index, and lower prevalence of vigorous leisure activities. This evidence concerns the gene F2 and metabolic dysfunction-associated steatotic liver disease.