DNAm analysis by pyrosequencing was performed for amplicons of the genes PDE4C, ELOVL2, RPA2, EDARADD and DDO. Furthermore, an epigenetic age-prediction model was trained for 11 age-associated CpGs for healthy children and adolescents, which was subsequently applied to the young individuals with growth disorders. Here, PDE4C is linked to hereditary endocrine growth disease.