After the establishment of HDM-induced asthma, we found that although the infiltration of eosinophils into the BALF and lungs and that of IL-4+CD4+ T cells and IL-13+CD4+ T cells into the lungs were higher in IRF8ΔDC mice than in WT mice, infiltration was comparable between IRF8ΔDC mice and IRF8/p38αΔDC mice (Fig. 3h, i). The gene discussed is IL4; the disease is asthma.