PKN2 and cancer: As concerns regarding the risk of malignancy and major adverse cardiovascular events (MACE) in patients treated with tofacitinib have been raised by the European Medicines Agency, it is important to consider the potential role of PKN2 inhibition61, However, in mice models, PKN2 activation was the cause of cardiac dysfunctions58, and therefore, the clinical impact of PKN2 inhibition is contradictory to the risk of cancer and MACE in rheumatoid arthritis patients.