ACVR2A and pulmonary arterial hypertension: We speculate that the breadth and robustness of ActRIIA-Fc activity revealed here in experimental PAH, attained through mutually reinforcing effects on pathogenic components of inflammation and cardiopulmonary remodeling, could potentially translate to disease-modifying activity of sotatercept in patients with PAH, as either a monotherapy or add-on to currently available therapies for PAH.