Strikingly, when we examined the mutational profile of our cohort, including the common recurrent somatic mutations, AML cases harbouring rare variants in mitochondrial complex I were conspicuous for the absence of the IDH1 R132 mutation (P = 0.05, Fisher’s exact test, Supplementary Data 2 and Supplementary Figure 1a). The gene discussed is IDH1; the disease is acute myeloid leukemia.