IDH1 and acute myeloid leukemia: This revealed that mtDNA-encoded complex I variants also display near-complete exclusivity with IDH1 mutations (FDR = 3.26 × 10−5, weighted exclusivity test, Fig. 1c), which was not observed for mtDNA variants and IDH2. A similar pattern of exclusivity was observed for mtDNA variants in the AML TCGA data25 (FDR = 0.03, weighted exclusivity test, Supplementary Fig. 1b).