Moreover, although the mRNA level of CDC73 in patients is statistically lower in TNBC than non-TNBC, there is an overlapping between them, and the regulation of UBR5 to CDC73 was also observed in non-TNBC cell line MCF-7, indicating that the function of CDC73 and UBR5 may be more wide spread in breast cancers, not limited to TNBC. This evidence concerns the gene UBR5 and breast cancer.