In view of the glomerular-tubular interplay in protein handling, the concept of DKD as a glomerulo-tubular disorder, and existing data supporting increased excretion of UfRBP4, KIM-1 and microRNAs in patients with longstanding DM, we designed the present study to explore several potential kidney injury biomarkers in children and young adults with different durations of T1DM. The gene discussed is HAVCR1; the disease is type 1 diabetes mellitus.