Here we describe the protocol of TB Screening Improves Preventive Therapy Uptake (TB SCRIPT), a randomized controlled trial conducted in three health centers in Uganda, which was designed to determine if TB screening based on POC CRP concentration improves clinical outcomes (reduced TB incidence and mortality) among outpatients with advanced HIV initiating ART through improved TPT uptake and detection of prevalent TB cases. This evidence concerns the gene CRP and tuberculosis.