Interestingly, RORA, acting as a potent tumor suppressor, was downregulated in several cancers, such as breast cancer and colorectal cancer, which inhibited cancers’ growth through attenuating Wnt/beta-catenin signaling, inducing SEMA3F expression or stabilizing p53 to activate apoptosis [59–61]. This evidence concerns the gene SEMA3F and breast carcinoma.