Although the antitumor efficacy of combination blockade of PD-L1 and IL-6 was similar with anti-PD-L1 drugs and paclitaxel in mice studies, lower PD-L1 expression and lower infiltration of immunosuppressive cells was found in the tumor microenvironment in the anti-PD-L1 drugs combined with anti-IL-6 inhibitors. This evidence concerns the gene IL6 and neoplasm.