Recently, the concept of the tumor immune microenvironment (TIME) has attracted increasing interests, which is composed of tumor-infiltrating immune cells (TICs), including natural killer (NK) cells, T cells (CD8, CD4), Treg, dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and so on [6]. The gene discussed is CD4; the disease is neoplasm.