NFKB1 and neoplasm: As it appears in the literature, microorganisms and microbial elements such as lipopolysaccharides (LPS) can up-regulate Toll-like Receptors (TLR)s, which can provoke activation of nuclear factor-kB (NF-kB), which is critical for controlling tumor-associated inflammation57,58, invasion, growth, survival, and immunosuppression59.