Comparing large, publicly available databases of the incidence of hematological malignancies (HL, NHL, MM, LEU) and the average yearly antibiotic consumptions (2009–2019) published in the ECDC yearly reports from 30 European Countries, indicates the possible role of certain antibiotic classes (tetracycline /J01A/, penicillin /J01C/, narrow spectrum, beta-lactamase resistant penicillin /J01CF/) in the development of some hematological malignancies (HL, NHL, MM, LEU). This evidence concerns the gene LACTB and Miyoshi myopathy.