The results indicated that elevated CD68 was observed in many tumor types, including COAD, GBM, KIRC, KIRP, LGG, OV, PAAD, READ, SKCM, STAD, TGCT, and UCS, and was associated with a more unsatisfactory clinical outcome in GBM, KIRC, LGG, LIHC, LUSC, THCA, and THYM. Here, CD68 is linked to glioblastoma.