Elevated levels of CD68 were significantly related to poorer OS in GBM (hazard ratio [HR] 1.05, 95% confidence interval [CI] 1.00–1.09, P = 0.0370), KIRC (HR 1.04, 95% CI 1.0–21.06, P = 0.0007), LGG (HR 1.18, 95% CI 1.06–1.31, P = 0.0020), liver hepatocellular carcinoma (LIHC) (HR 1.06, 95% CI 1.02–1.11, P = 0.0058), lung squamous cell carcinoma (LUSC) (HR 1.04, 95% CI 1.00–1.08, P = 0.0470), thyroid carcinoma (THCA) (HR 1.17, 95% CI 1.06–1.29, P = 0.0023), and thymoma (THYM) (HR 1.47, 95% CI 1.08–2.00, P = 0.0130) (Fig. 3). Here, CD68 is linked to thymoma.