CDK12 and ovarian serous carcinoma: We also noted that the peculiar poor prognostic behavior of CDK12NULL patients is in good agreement with the previously reported association between complete CDK12 loss-of-function and impaired DDR, high genomic instability and aggressive disease course, as observed in high-grade serous ovarian carcinoma and metastatic castration-resistant prostate cancer8,10,32–34.