Regardless, both CDK12-KI/PyMT and CDK12-KI/NeuN female mice displayed a higher propensity to develop multiple spontaneous lung metastases compared to control WT/PyMT and WT/NeuN mice sacrificed at the same endpoint (i.e., primary tumor size ~1.2 cm) (Fig. 2d, e; Supplementary Fig. 2d, e). This evidence concerns the gene CDK12 and neoplasm.