UCP1 and obesity due to melanocortin 4 receptor deficiency: They proposed various pathways and genes related with the regulation of lipid synthesis and fat metabolism.[9] Liu et al reported that FSH antibody reduces body fat in all compartments, namely viscera, subcutaneous tissue, and bone marrow by increasing Ucp1 (uncoupled protein 1) in mouse model.[28] Although previous clinical studies have shown that obesity has an inhibitory effect on FSH levels, experimental studies have reached an opposite conclusion.