The authors concluded that a low FSH level was associated with an increased waist circumference and HOMA-IR and is consequently a risk factor for prediabetes and diabetes.[12] Another clinical study also showed that higher FSH levels were associated with lower prevalence and incidence type 2 DM and fasting insulin levels in postmenopausal women.[29] Our study showed a negative association between the factors of insulin resistance and FSH after adjustment for BMI and the estradiol level like clinical studies mentioned above. The gene discussed is INS; the disease is prediabetes syndrome.