LEP and obesity due to melanocortin 4 receptor deficiency: Estrogens regulate various aspects of glucose and lipid metabolism and adipokines secretion, and estrogen deficiency leads to increased obesity and abdominal obesity, hyperlipidemia, impairment of glucose metabolism, and insulin resistance.[17–19] Circulating adipokines including leptin and adiponectin secreted by adipose tissue modulate energy homeostasis such as obesity, insulin resistance, and metabolic syndrome and underlying FSH change according to menopause stage is associated with change in adipokine levels.[1,2]