They proposed various pathways and genes related with the regulation of lipid synthesis and fat metabolism.[9] Liu et al reported that FSH antibody reduces body fat in all compartments, namely viscera, subcutaneous tissue, and bone marrow by increasing Ucp1 (uncoupled protein 1) in mouse model.[28] Although previous clinical studies have shown that obesity has an inhibitory effect on FSH levels, experimental studies have reached an opposite conclusion. This evidence concerns the gene UCP1 and obesity disorder.