While ectopic overexpression of FER dramatically increased tyrosine phosphorylation and PIK3R2 recruitment of IRS4, CRISPR-Cas9 directed KO or pharmacological inhibition of the endogenous kinase in ovarian cancer cells remarkably reduced tyrosine phosphorylation and PIK3R2 recruitment of IRS4. The gene discussed is IRS4; the disease is ovarian carcinoma.