Consistent with our previous findings in cell cultures, the tumor growth in mice injected with OVCAR-5 IRS4-KO cells rescued with 5YF IRS4 was profoundly delayed compared to WT control (Figure 6G), further emphasizing the necessity of the tyrosine phosphorylation of key residues in IRS4 for ovarian tumorigenesis and progression. The gene discussed is IRS4; the disease is neoplasm.