The results showed that high expression of EGFR was associated with sensitivity to some of the small molecular drugs (Lapatinib, Gefitinib, Erlotinib, Cetuximab, Afatinib, et al.); while high expression of CDKN1B was sensitivity to Vorinostat; high expression of BAK1 was sensitivity to Z-LLNle-CHO (Fig. 7), which further support the autophagy-signature for the potential optimization of targeted therapy in patients with GBM. This evidence concerns the gene EGFR and glioblastoma.