Our results showed that these predicted targets are associated with multiple pathways, such as the insulin signaling pathway, phosphatidylinositol 3 kinase (PI3K)–Akt signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, the estrogen signaling pathway, and insulin resistance, which are related to obesity and the menopause (Table 1). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.