In addition, Natasha A Winter et al. found that the gene expression of TPSAB1/TPSB2 and CPA3 correlated with sputum mast cells/basophils, and in severe asthma, TPSB2 and CPA3 were associated with eosinophilic airway inflammation and blood eosinophils [25]. The gene discussed is TPSB2; the disease is asthma.