We found that inhibition of CaMKII α-hM4Di+ DCN neurons during noise exposure did not prevent startle suppression deficit after noise exposure compared to the initial screening (n = 6; 67.5 ±6.8% pre-NE; 5.3 ±2.2% post-NE + NaCl; F = 114.2, p = 1.2e −4; Fig. 5F), indicating that lowering CaMKII α-hM4Di+ DCN cell activity could not prevent noise-induced tinnitus-like behavior. This evidence concerns the gene CAMK2G and Tinnitus.