We first detected the mRNA levels of CFHR3, EGLN3 and CHGA in HCC cell lines (Hep3B, Huh-7, JHH-7, Li-7, QGY-7701, SK-Hep-1, SNU-398, SNU-423, HepG2 and SMMC-7721) and normal hepatic epithelial cells (LO2). This evidence concerns the gene EGLN3 and hepatocellular carcinoma.