GSEA analysis revealed that hypoxia in HCC was positively associated with E2F targets (NES = 2.69), G2/M checkpoint (NES = 2.62), and MYC targets (NES = 2.46), but was negatively associated with bile acid metabolism (NES = −2.64) and fatty acid metabolism (NES = −2.03) (Figure 1(d)). The gene discussed is MYC; the disease is hepatocellular carcinoma.