The results of the ROC analysis indicated that CFHR3 had a remarkable diagnostic value (AUC = 0.711) in serum specimens for distinguishing Patients with HCC from healthy controls, whereas EGLN3 (AUC = 0.594) and CHGA (AUC = 0.549) had no diagnostic value (Figure 7). This evidence concerns the gene CFHR3 and hepatocellular carcinoma.