Furthermore, within individuals with T2DM Ang2 levels (in ng/mL) were significantly higher in individuals with CAD (1.69 vs 0.820, p = 0.049) and PAD (2.060 vs 0.820, p = 0.0013) compared to individuals with T2DM without MVD (Fig. 3d). Here, ANGPT2 is linked to peripheral arterial disease.