However, we observed that the percentage of Tie2+ monocytes was significantly increased (p < 0.05) in the intermediate monocyte subset in individuals with T2DM with and without MVD (57.5 ± 5.8% Tie2+ cells) compared to healthy controls (30.2 ± 9.8% Tie2+ cells, Fig. 2d). Here, TEK is linked to type 2 diabetes mellitus.