TERT and nonpapillary renal cell carcinoma: Because TERT promoter mutations are frequent in ccRCC, while GABPA is required to activate the mutant promoter [4, 18, 21], we further analyzed TERT expression and observed its upregulation in those ccRCC tumors (NTs vs tumors, P < 0.001), which was contrast to downregulation of GABPA in tumors (Fig. S1).