To accomplish this, we treated ZBP1+/+ and ZBP1−/− derived astrocytes with both a RIPK3 inhibitor (GSK872) and a pan caspase inhibitor (zVAD-FMK) following infection with HSV-1(MacIntyre), HSV-1(F), and HSV-1(F)-ICP6-RHIM Mut strains. Here, RIPK3 is linked to infection.