The percentage of cell death at 24 h (Figs. 2 and 6A) and kinetics of cell death remained significantly different between ZBP1+/+ and ZBP1−/− derived astrocytes in the presence of GSK936 and zVAD-FMK following challenge with either HSV-1(F) or HSV-1(F)-ICP6-RHIM Mut, indicating that caspase inhibition permits RIPK1-mediated necroptosis following infection. Here, ZBP1 is linked to infection.