In 204 breast cancer patients, NEDD9 expression was significantly correlated with tumor grade (χ2 = 4.311, P = 0.038), ER (estrogen receptor) (χ2 = 11.16, P = 0.001), PR (progesterone receptor) (χ2 = 4.026, P = 0.045), Ki67 (χ2 = 6.558, P = 0.01) and lymphatic metastasis (χ2 = 14.79, P = 0.0001). This evidence concerns the gene PGR and breast cancer.