It can reverse the chemotherapy resistance of colon, nasopharyngeal, and lung cancer cells by targeting Wnt/β-catenin, SMAD7 (SMAD family member 7), and GPX4 (glutathione peroxidase 4) [13–18], and also regulates the progression of breast and pancreatic cancers by regulating ferroptosis and angiogenesis, respectively [15,44]. The gene discussed is SMAD7; the disease is lung carcinoma.