Both in vitro andin vivo, IL-10 was shown to increase Fc receptors on myeloidcells in the circulation of RA patients treated with IL-10.12 Nonetheless, in experimental in vitro and invivo models, IL-10 (and IL-4) strongly prevented inflammation-inducedcartilage degeneration, with combining both cytokines having additive effects. The gene discussed is IL4; the disease is rheumatoid arthritis.