BARD1 and cancer: The BARD1 BRCT Cys645Arg, Val695Leu, and Ser761Asn mutations are identified as cancer predisposing in nature (Fig. 1A, ESI†), and significantly affect the tumor-suppressor functions of the BARD1.15 The ΔΔG° value predicted by I-mutant 3.0 (ref. 32) is tabulated in Table 1 (ESI†).