NKX2-2 and cancer: In the central nervous system, FEV expression is controlled by a serotonergic transcriptional cascade that consists of the homeodomain factor Nkx2.2 [24], proneural factor Mash1 [25], the zinc finger factor Gata-2 in postmitotic precursors [26], and the forkhead box factor Foxa2 [27] in the ventral hindbrain progenitors, and gene fusion with ETS members caused by chromosomal translocation is frequent in human cancers.