Taken together, mIL‐6R blockade by the h‐mIL‐6R mAb alleviated excessive inflammatory responses and organ dysfunctions of the LPS‐induced SIRS in the IL6r‐e(hIL6R)1 mice, potentially through inhibiting NF‐κB‐regulated inflammation and pyroptosis of monocyte. This evidence concerns the gene NFKB1 and systemic inflammatory response syndrome.