TARDBP and amyotrophic lateral sclerosis: The mislocalization and cytoplasmic ubiquitinated inclusions of transactivation response DNA-binding protein 43 kDa (TDP-43) are the major neuropathological hallmark in Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD; Neumann et al., 2006; Mackenzie et al., 2010).