TDP-43 consists of an N-terminal domain (NTD: residues 1–76) with a well-defined globular folded structure, two highly conserved RNA recognition motifs (RRM1: 106–176 and RRM2: 191–259), and an unstructured, glycine-rich C-terminal domain (CTD: 274–414) which harbor most of the pathologically linked ALS-mutations (Buratti, 2015) and display greater ability to self-assemble, phase separate, and aggregate (Colombrita et al., 2009). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.