TDP-43 is also associated with tau-negative frontotemporal lobar degeneration (Liscic et al., 2008), and in the cases with Alzheimer’s (AD), Parkinson’s (PD), and Huntington’s (HD) diseases (Rohn, 2008; Schwab et al., 2008; Chanson et al., 2010), although they are not considered as a primary target in these cases. Here, TARDBP is linked to frontotemporal dementia.