CD4 and myeloid sarcoma: In an miRNA profile study of naïve CD4 + T lymphocytes in MS patients, Severin et al. (2016) identified 12 differentially expressed miRNAs that were validated using qRT-PCR and predicted to target the TGF-β signaling pathway, including: miR-18a, -27b, -103a, -128, -141, -212, -500a, -628-3p, -708, let-7a, -7b, and -7f.