Human leukocyte antigen (HLA)-E-restricted CD8+ regulatory T lymphocytes can be induced by IFN-γ, which can kill immune cells such as CD4 + T lymphocytes and induce other cells to secrete some inhibitory factors such as TGF-β; IL-10 suppresses immune function and maintains disease stability in MS patients in remission (Frisullo et al., 2010). This evidence concerns the gene CD8A and myeloid sarcoma.