Another miRNA genome-wide expression profile by microarray analysis on CD4 + T lymphocytes showed the miR-25 and miR-106b expression is downregulated in RRMS patients; these two miRNAs may regulate the TGF-β signaling pathway and Tregs differentiation and maturation by modulating CDKN1A/p21 and BCL2L11/Bim (De Santis et al., 2010). This evidence concerns the gene BCL2L11 and relapsing-remitting multiple sclerosis.