Moreover, Torres et al. assessed the effect of a MD in 60 patients with RA and high cardiovascular risk according to the Framingham risk score in comparison with a standard diet, and they reported decreases in the concentrations of TNF-α (2.1 vs. 1.2 pg/mL,p < 0.001) and IL-6 (3.8 vs. 2.53 pg/mL, p < 0.001) in the MD group (40). This evidence concerns the gene TNF and rheumatoid arthritis.