Interestingly, the negative association between gynoid fat (%) and fasting insulin in women also supports other findings, including one study in obese adolescents showing HOMA-IR value having a significant positive association with android to gynoid fat ratio (%) and another more recent cross-sectional study showing peripheral fat, including gynoid fat being protective against insulin resistance in both women and men (43). The gene discussed is INS; the disease is Insulin resistance.