Amplification of MCL1 (24/58, 41.4%), FGF19 (23/58, 39.7%), CCND1 (22/58, 37.9%), and MYC (20/58, 34.5%) was the four dominant types of CNV identified in this ESCC cohort. The gene discussed is CCND1; the disease is esophageal squamous cell carcinoma.