In heart failure, the most relevant genes upregulated in endothelial cells are mainly related to cell adhesion, angiogenesis, and cell migration (major histocompatibility complex, class I, B, HLA-B; EGF like domain multiple 7, EGFL7; receptor activity modifying protein 1 and 2, RAMP1, RAMP2; plasmalemma vesicle associated protein, PLVAP; inhibitor of DNA binding 1, ID1; and formin like, FMNL3), inflammatory response (CX3CL1; cluster of differentiation 74, CD74), as well as development and maturation (SOX17, SOX18) (73). This evidence concerns the gene EGFL7 and heart failure.