CCN4 and coronary artery disorder: Interestingly, myocardial biopsies of patients suffering from ischemic heart disease also show increased expression of CKAP4 in fibroblasts, accompanied by activation of other genes such as POSTN, WNT1-inducible signaling pathway protein-1 (WISP1), and tenascin C (TNC) (24) as well AE binding protein 1 (AEBP1) a novel transcription factor identified in human cardiac fibrosis (46).