GLA and Fabry disease: Fabry disease is a X-linked lysosomal storage disorder caused by enzyme α-Galactosidase A (α-Gal A) deficit due to GLA gene mutations, leading to progressive tissue accumulation of glycosphingolipids, especially globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3).