CAT and Ventricular arrhythmia: Considering that some previous studies demonstrated that H2O2 could acutely modulate voltage-gated Ca2+ channels (36–38), in the present study, we used in vivo transfection of adenoviral catalase gene (Ad.CAT) in the AVG to reveal the involvement of H2O2 in CVP neuronal dysfunction, ventricular vagal abnormality, and MI-evoked ventricular arrhythmias in T2DM.