Ad.CAT gene transfection into CVP neurons significantly increased T2DM-reduced total Ca2+ currents (42.2 ± 1.6 pA/pF), N-type Ca2+ currents (25.7 ± 1.3 pA/pF), and cell excitability of CVP neurons, compared to T2DM rats without Ad.CAT gene transfection (Figures 3, 4, Supplementary Figure 3). Here, CAT is linked to type 2 diabetes mellitus.