For the first time, we successfully attenuated the oxidative stress through in vivo gene transfection of Ad.CAT into CVP neurons in T2DM rats, as evidenced by an increase in catalase activity, protein expression of catalase, and a subsequent decrease in H2O2 levels in CVP neurons at 1 week after Ad.CAT gene transfection (Figures 1, 2). Here, CAT is linked to type 2 diabetes mellitus.