We then measured the catalase protein (an endogenous H2O2 scavenger) and found that its expression in CVP neurons was much lower in T2DM rats than that in sham rats (0.22 ± 0.01 in the T2DM group vs. 0.71 ± 0.01 in the sham group, P < 0.05, Figures 2A,B). The gene discussed is CAT; the disease is type 2 diabetes mellitus.