When Ad.CAT gene was microinjected into the AVG from T2DM rats, the expression of catalase protein in CVP neurons was significantly elevated (0.92 ± 0.01 in the T2DM+Ad.CAT group), compared to T2DM rats without Ad.CAT gene transfection (0.22 ± 0.01 in the T2DM group, P < 0.05, Figures 2A,B). The gene discussed is CAT; the disease is type 2 diabetes mellitus.