When Ad.CAT gene transfection into CVP neurons increased over the expression and activity of catalase, decreased intracellular H2O2 levels, restored protein expression and ion currents of N-type Ca2+ channels, and increased intracellular Ca2+ levels and cell excitability of CVP neurons in T2DM rats (Figures 1–5), we believe that intracellular H2O2 elevation causes the reduction of N-type Ca2+ channel expression and activation in CVP neurons and the latter decreases intracellular Ca2+ levels and cell excitability of CVP neurons in T2DM rats. Here, CAT is linked to type 2 diabetes mellitus.