In our present study, Ad.CAT gene transfection into CVP neurons decreased intracellular H2O2 levels, enhanced protein expression and ion currents of N-type Ca2+ channels, and increased intracellular Ca2+ levels and cell excitability of CVP neurons in T2DM rats (Figures 1–5), which confirms that H2O2 is the primary trigger to induce changes of these variables in CPV neurons from T2DM rats. Here, CAT is linked to type 2 diabetes mellitus.