Ad.CAT gene transfection into CVP neurons partially restored T2DM-reduced protein expression of N-type Ca2+ channels (0.53 ± 0.02 in the T2DM+Ad.CAT group vs. 0.32 ± 0.01 in the T2DM group, P < 0.05, Figures 2C,D). This evidence concerns the gene CAT and type 2 diabetes mellitus.