Since the effects of NEU1 inhibition on SIRT1/PGC-1α axis protein are eliminated by independently inhibiting SIRT1 activity (EX527) or PGC-1α expression (with SR-18292), our data indicated that there is a strong association between SIRT1/PGC-1α pathway-mediated NEU1 and mitochondrial biogenesis, with important potential implications for HF post-MI. Here, SIRT1 is linked to myocardial infarction.