IONIS-APO(a)Rx, an oligonucleotide targeting lp(a), could reduce lp(a) levels by 66–92%, OxPL-ApoB and OxPL-apo(a) decreased moderately, which play a vital role in pathogenesis of CAVD (71). Here, APOB is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.