HLA-B*15:02 is firstly reported to be strongly associated to carbamazepine (CBZ)-induced SJS/TEN in Chinese population (odds ratio [OR] = 2504) (Chung et al., 2004), and the association is latterly validated in different populations, such as Thai, Malaysian, Chinese, and Indian patients (Hung et al., 2006; Locharernkul et al., 2008; Mehta et al., 2009; Tassaneeyakul et al., 2010; Cheung et al., 2013; Tangamornsuksan et al., 2013; Chung et al., 2016b). The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.