AKT1 and major depressive disorder: In addition, based on the KEGG pathway data analysis, we found that the PI3K-Akt signaling pathway, ubiquitin-mediated proteolysis, estrogen signaling pathway, MAPK signaling pathway, and TGF-beta signaling pathway concurrently occupied the process of YZQX treatment of comorbidity with AD and MDD (Figure 5E).