Promising targets (HSP90AA1, ESR1, AKT1, VCAM1, EGFR, CDK1, MAPK1, CDK2, MYC, HSPB1, and HSPA5) and signaling pathways (PI3K-Akt signaling pathway, ubiquitin-mediated proteolysis, MAPK signaling pathway, etc.)were filtered and refined to elucidate the underlying mechanism of YZQX against AD and MDD comorbidities. This evidence concerns the gene HSPB1 and major depressive disorder.