The PPI network indicated that HSP90AA1, ESR1, AKT1, VCAM1, EGFR, CDK1, MAPK1, CDK2, MYC, HSPB1, and HSPA5 are pivotal targets in the core network mentioned above, and these nodes were also overlapping genes of AD and MDD comorbidity. Here, HSPA5 is linked to major depressive disorder.