Promising targets (HSP90AA1, ESR1, AKT1, VCAM1, EGFR, CDK1, MAPK1, CDK2, MYC, HSPB1, and HSPA5) and signaling pathways (PI3K-Akt signaling pathway, ubiquitin-mediated proteolysis, MAPK signaling pathway, etc.)were filtered and refined to elucidate the underlying mechanism of YZQX against AD and MDD comorbidities. Here, ESR1 is linked to major depressive disorder.