Next, among the top 20 upregulated genes by G-CSF, genes associated with poor prognosis (Logrank p < 0.05) in more than four cancers, including Nos2, proprotein convertase subtilisin/kexin type 9 (Pcsk9), PRKC apoptosis WT1 regulator (Pawr), and gamma-glutamyltransferase 1 (Ggt1), were identified as candidate factors involved in the immunosuppressive ability of MDSCs using the GEPIA web server (Tang et al., 2017) (Supplementary Figure S1). This evidence concerns the gene CSF3 and cancer.