Origin re-licensing accompanied by CDT1 overexpression or Geminin down-regulation, induces DNA re-replication in different cancer cell lines, promoting the activation of the DNA damage response, inhibition of DNA synthesis and cell cycle arrest in S or G2 phase (Klotz-Noack et al., 2012; Muñoz et al., 2017; Zhou et al., 2020). The gene discussed is GMNN; the disease is cancer.