Possible explanations could be the following: (1) TRPC1 expression was correlated with more advanced T stage and TNM stage, which might indirectly bring in shorter OS; (2) TRPC1 related to high EMT and invasive ability of RCC cells, which is associated with a high relapse risk, thus TRPC1 protein high was correlated with poor survival profile (12). The gene discussed is TRPC1; the disease is renal cell carcinoma.